Prior to establishing her own firm, Toshiko Mori worked for Edward Larrabee Barnes. Mori is licensed as an architect in Connecticut, Florida, Maine, Massachusetts, Michigan, Minnesota, Missouri, New Jersey, New York, Rhode Island, and Washington, D.C.. At the Harvard University Graduate School of Design, she received tenure in 1995 and chaired the Department of Architecture from 2002–2008. Mori has taught at the graduate level at Cooper Union School of Architecture, Columbia University, and Yale University.
Mori is known for her "concern with material innovation and conceptual clarity." Her projects include the A.R.T. New York theater, the canopy at the Brooklyn Children's Museum, Pembroke Hall at Brown University, exhibit design at MoMA and the Cooper Hewitt, Smithsonian Design Museum, and numerous residential projects in the United States, Taiwan, China, and Austria.
As a member of the World Economic Forum's Global Agenda Council on the Future of Cities, Mori leads research and inquiry into sustainable architecture, enhancing cities' livability, and creating efficient urban services. Mori is also on the board of directors of Architecture For Humanity, a nonprofit dedicated to design innovation and community involvement.
She has been the recipient of numerous international awards and honors, and her work has been widely exhibited and published. She was awarded the Cooper Union's inaugural "John Hejduk Award" in 2003. In 2005, she received the "Academy Award in Architecture" from the American Academy of Arts and Letters, as well as the "Medal of Honor" from the American Institute of Architects New York Chapter. Her projects have been exhibited in the Cooper-Hewitt National Design Museum’s “Design Life Now: National Design Triennial 2006” and at the Guggenheim Museum.
A monograph of her work, "Toshiko Mori Architect, "was published by Monacelli Press in 2008. She has contributed to many publications, as well as editing a volume on material and fabrication research, "Immaterial/Ultramaterial."